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Scientists are working on ways to treat and prevent autoimmune diseases like Crohn’s, multiple sclerosis and type 1 diabetes with worm therapy. Dr....
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-- Hello welcome to -- -- I'm Dr.
Manny.
What if -- told you that cup filled with worms.
Might prevent type one diabetes found -- you know.
But there might be something to this science joining me now to explain is the chief medical officer of Coronado biosciences.
Doctor -- and he hamburger welcome -- and as I say sounds crazy you know.
-- to prevent type one diabetes.
Let's clear up I think for a lot of folks what kind of -- so we talking about.
So TSO stands for treacherous in this nova and us has really not worms that's the pig with form.
Apple but so these are the eggs from the -- -- -- and that we give them and solution so it's essentially live quit.
That is a saline solution.
And these -- are microscopic you can't see them.
They're -- it last taste less but they big growth from an old but would use -- -- -- actual little microscopic worms that's writes I cannot you can never see them.
We'll let them even and just do -- that he probably -- they don't -- -- they gotta say I don't wanna have words in my belly but I get it no so we.
What how do they weren't -- how does having these microscopic worms in Europe flora of your intestines.
Help you prevent diabetes so this is all based on the hygiene hypothesis.
So what is interesting is that while we are now able to combat in factions -- -- they used to kill us before.
-- hygiene was implemented in the kind of western world it's we are now seeing an increase in autoimmune disease so.
Type one diabetes is an auto immune to cities is a chronic disease where the body itself the immune system as hurting.
Itself and in the -- in the case of type one maybe this is the pancreas.
The pancreas is the organ that produce a sense of them it's -- -- incidence from the beta cells so by -- having these -- -- firm nova.
That grow into microscopic -- -- larvae but you cannot say.
You're -- setting the immune systems you re setting the balance.
So that instead of attacking itself.
The immune system is attacking what it's supposed attack which -- the outside bacteria virus and so on so what other diseases has been treated by this one therapy him.
So -- started out -- inflammatory bowel disease and Crohn's Disease and also -- -- where we have proof of concept data from many studies in the ninety's and that's what we are also conducting -- -- phase two trial.
We're also doing trials and -- -- at NYU -- -- and one more place.
We're also looking at MS multiple sclerosis so we have proof of concept data and multiple sclerosis.
Small study from the University of Wisconsin -- conducting a larger study there as well.
There's another study in and that's in Europe at Sharif -- in Berlin.
We're also.
In rheumatoid arthritis also in Europe and most recently we -- started and announced a study in optimism.
-- -- you about that.
I present an autistic children -- child myself and I know that.
The immune aspect of -- is very important.
Yes and this is a recent finding it has not been discussed much in the past but so there's a lot of data right now that in autism.
There's an immunology component one makes you think that is going to.
Help with content type one diabetes -- what base.
Appreciation being done now so in -- -- debuted as number one it is an autoimmune disease we know that for a fact we know that this to -- Is a typical -- indices because.
Before the diagnosis of type and ideas which is based on glucose measure glucose if the sugar is high.
You have to ideas that's a definition but we know that in type -- ideas.
The deceased -- much that it and that by the immune system starting to.
To hurt itself we can measure that threw off to antibodies so we notes are not immune disease that's number one number two.
There are many animal experiments done now there's a special -- model for type one diabetes called the knowledge and mouse and in the nod mouse.
We can prevent type fund ideas from happening -- is from happening in this -- By using helmets and -- is so being -- comment all right you have a clinical trial going on right now talk to me about that.
Yes so -- large clinical trial which is are the Coronado sponsored trial.
Is called trust one.
And this is a trial and Crohn's Disease we are enrolled in 220 patients.
Over about 65 sites and the -- last.
In panel of that we have another clinical trial in Europe.
Another about 250 patients.
In Europe and five countries so those two trials are are too large trials and that's going on right now -- now you also going to start a new trial on the treatment of type one diabetes -- -- When is that happening so we are actually looking at three different kinds of trials in type one -- it is were very excited.
So these different trials -- -- and prevention of type one -- -- this.
Where we are able to identify people -- risk and here we are targeting young children.
Because in children the new system is still it's not static so we believe that we can.
Make more of a change and children that we -- adults.
So we're targeting children at risk for developing type fund ideas to -- -- immune system so that they never have to develop this very.
Difficult to cities.
The other trial that we're looking at is in children and adults who have been recently diagnosed.
So this called recent onset where there's an intervention trials and the reason we're also looking at this is that if we can prevent further destruction.
Of the beta cells in the pancreas.
We can reduce the need for some audience -- -- that is required in type and -- Venus.
So the aim is to look at that now what is the FDA -- and all these trials on the monitoring -- -- sponsor of the trials yes that we we have we have worked very closely with the FDA.
We have -- -- open.
For our crohn's indication that he and down and had the other trials that were considering.
Are -- investigator initiated so that means that the investigator has to -- To start a trial in and the different indications type -- -- being one of them.
A lot of folks are gonna be asking questions because again it's very difficult for people and are not into the science world to understand larva.
But these worms have for these -- by have cash and short life.
In other -- they get ingested they grow they died off.
Yeah so the good thing about our product -- -- so is that the human being is not the natural host.
It is the page that is a natural host so and the human being there's -- -- short -- -- and that's why these these larvae.
Do not.
Develop into full grown.
Reproductive worms so they cannot produce additional Slovak.
And they cannot become more -- can't grow they can't -- -- -- the -- Austin so it's actually the perfect drug because it's only there.
It's I think I would compare it to drug patch for about two weeks.
It sits there excerpts it's a fact on the immune system and then it dies off and -- -- -- and it's completely and then you keep -- items that just.
You keep exciting the immune system to focus in a different direction -- tonight from your body.
-- on a final note.
You keep this is a very personal story to you because you suffered from type one diabetes right.
Yes IA I was diagnosed as a sixteen year old and I was so very.
Active sixteen year old I was playing tennis almost capacity at the time in Sweden.
And -- was diagnosed and that that really changed my life I mean in a good way too because I went to medical school and studied.
And also got a Ph.D.
and I beat us but I.
Spent not my career focusing an understanding diet need to spend twenty years later it's.
Idea developed complications decide if that's -- serious complications died in this and it went very fast.
And die -- required a kidney so my father who.
Is my hero and I gave me one of his kidneys so that I did not have to go on dialysis and -- the media and it is suffering cannot.
And then nine months after the kidney transplant and January of 2010 I have received the pancreas.
So in my case I've seen how it is to live a -- young person teenager.
With no -- this then start being put twenty years woods went -- list.
And then having the complications so.
If I can do anything to prevent this disease and anyone else and as Michael -- -- well.
I tell you I think that this is one of the most fascinating stories that we have done here at fox.
And it's fascinating because you can't you you're attacking this from an angle.
Where you are telling the body how to heal itself and I think it's a wonderful story and I think is very important.
So that's why would I want you to tell everybody on there what can people get information so you can get information.
From our website Coronado biosciences dot com and -- also from creek clinical trials dot gov where the trial is register.
Well thank you so much is a great honor.
I'm gonna have be here as soon as you have some data from the trials -- I think a lot of folks out there.
Are going to be very interested in knowing exactly how the trials going and -- this is going to be something that is and work for them so thank you so much thank you so much all right.
-- you have any health questions you can send email here too far outside -- -- -- functions dot com.
-- -- next time on document.
